Adaptive Control of Insulin Delivery for Diabetic Patients

The complications of diabetes are thought to arise from poor control of blood glucose concentration because of inadequate secretion of insulin by the pancreas. This has motivated the undertaking of novel therapeutic approaches to improve insulin delivery.

Present insulin administration requires insulin injections which, even in their simplest form of the Novo-pen system, are cumbersome and undesirable by the patient. Controlled drug delivery technologies can be used to our advantage to provide delivery of insulin over a period of time at specified rates. Indeed, as we show below, controlled drug delivery(CDD) systems can be developed to release insulin only when the glucose level in the blood is abnormally high.

The goal of this project is to design adaptive controllers such as the adaptive lambda-tracker and demonstrate how much improvement these controller yield compared to standard controllers.

Supervisors

• Eric Bullinger
• Prof. Frank Doyle
• Prof. Frank Allgöwer