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Mathematical Modeling of Signal Transduction in Cellular Life and Death Decisions

Overview - Background - Projects -

Signal Transduction refers to the process by which cells perceive their environmental or internal status and react to such stimuli with appropiate physiological responses. Cytokines, such as Tumor Necrosis Factor (TNF), thereby bind to their respective receptors elicting a signal that is propagated, amplificated and integrated, finally leading to altered gene expression or protein activity. This can cause the cell, for example, to differentiate in oder to fulfill a specific task or to die.

The dynamic behavior is not only hard to predict, but sometimes even hard to understand, as signal tranduction is a highly non-linear process. Mathematical modeling and Systems Theory can significantly aid in understanding the molecular mechanisms and the underlying design principles in network structure and dynamics that execute signal transduction.

In collaboration with the Institute for Cell Biology and Immunology in Stuttgart we are investigating those principles at the example of the signal transduction elicted by TNF. However, some of those pathways can also be triggered by additonal signals, or a crosstalk with other signaling pathways might exists extending the realm of our interest.


image   Further information Eric Bullinger.
This project is funded by the Deutsche Forschungsgemeinschaft

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University Stuttgart      Logo University MagdeburgUniversität Magdeburg      Logo University of LiègeUniversity of Liège last modified by sysbio 25 May. 2009