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Mathematical Model aided understanding of Signal Transduction
Pathways at the example of Tumor Necrosis Factor (TNF) signaling
- Project 3: Modeling of TNF receptor clustering
Receptor clustering is not only important for initiation of a signal
in response to TNF, but an often found phenomena in biological systems.
Although models have been derived, several essential questions cannot be
considered to be finally resolved; e.g. why is clustering necessary, and
what is the minimal size of those clusters? A model specific for the TNF
receptors should be generated, hopefully also enabling to answer more global
questions. Cellular Automata will probably the method of choice here to
address these questions.
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