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Mathematical Model aided understanding of Signal Transduction Pathways at the example of Tumor Necrosis Factor (TNF) signaling

Overview - Project Background - TNF Background - Student Projects

- Project 1: Implementation and analysis of a TNF signaling network model

The knowledge in the field of signal transduction is evolving fast. The current implementation of the TNF signaling pathway was critically evaluated and showed room for further improvement. As well, new aspects should be integrated into the future model. The biological background is provided through a close collaboration with the Institute of Cell Biology and Immunology. In this project the implementation, parameter adjustment and analysis of the model will be mainly focused on. The model will consist of a large set of ordinary differential equations (ODEs) describing the change of relevant cellular compound concentrations over time. The simulation platform used will be MALTAB. The analysis should include a system theoretic point of view, as well as a biological point of view. In latter, the crosstalk between TNFR1 and TNFR2, as well as the decision between life and death will be a major focus.

- Project 2: Stochastic modeling of signal transduction at the example of (TNF induced) cellular suicide

- Project 3: Modeling of TNF receptor clustering



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University Stuttgart      Logo University MagdeburgUniversität Magdeburg      Logo University of LiègeUniversity of Liège last modified by sysbio 25 May. 2009