- Project 1: Implementation and analysis of a TNF signaling network
The knowledge in the field of signal transduction is evolving
fast. The current implementation of the TNF signaling pathway was critically
evaluated and showed room for further improvement. As well, new aspects
should be integrated into the future model. The biological background
is provided through a close collaboration with the Institute of Cell
Biology and Immunology. In this project the implementation, parameter
adjustment and analysis of the model will be mainly focused on. The model
will consist of a large set of ordinary differential equations (ODEs) describing
the change of relevant cellular compound concentrations over time. The
simulation platform used will be MALTAB. The analysis should include a
system theoretic point of view, as well as a biological point of view.
In latter, the crosstalk between TNFR1 and TNFR2, as well as the decision
between life and death will be a major focus.