|
|
|
Mathematical Model aided understanding of Signal Transduction
Pathways at the example of Tumor Necrosis Factor (TNF) signaling
|
- Project 2: Stochastic modeling of signal transduction at the example
of (TNF induced) cellular suicide
Currently a deterministic approach is used to model the behavior
of a cell. Data used for parameter adjustment are obtained from cell
populations. New technologies are enabling the study of processes
within a single cell. Those new insights indicate that stochastic processes
are probably very important in understanding cellular behavior. A stochastic
model focussing on the apoptotic pathway should aid understanding of TNF
induced apoptosis, as well as apoptosis in general. After the development
of the stochastic model, system theoretic analysis should be conducted and
the relevance for the biological system evaluated. Theoretical considerations
can extend this work.
|
|
|
ILS
Universität Magdeburg
University of Liège