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Mathematical Model aided understanding of Signal Transduction Pathways at the example of Tumor Necrosis Factor (TNF) signaling

Overview - Project Background - TNF Background - Student Projects

- Project 1: Implementation and analysis of a TNF signaling network model

- Project 2: Stochastic modeling of signal transduction at the example of (TNF induced) cellular suicide

Currently a deterministic approach is used to model the behavior of a cell. Data used for parameter adjustment are obtained from cell populations. New  technologies are enabling the study of processes within a single cell. Those new insights indicate that stochastic processes are probably very important in understanding cellular behavior. A stochastic model focussing on the apoptotic pathway should aid understanding of TNF induced apoptosis, as well as apoptosis in general. After the development of the stochastic model, system theoretic analysis should be conducted and the relevance for the biological system evaluated. Theoretical considerations can extend this work.

- Project 3: Modeling of TNF receptor clustering


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